天津中醫藥  2023, Vol. 40 Issue (5): 605-607

文章信息

田笑新, 丁寧, 王永濤, 等.
TIAN Xiaoxin, DING Ning, WANG Yongtao, et al.
從肝郁肺虛論治心臟神經官能癥的理論探討
Theoretical discussion on treating cardiac neurosis from liver depression and lung deficiency
天津中醫藥, 2023, 40(5): 605-607
Tianjin Journal of Traditional Chinese Medicine, 2023, 40(5): 605-607
http://dx.doi.org/10.11656/j.issn.1672-1519.2023.05.12

文章歷史

收稿日期: 2022-12-28
從肝郁肺虛論治心臟神經官能癥的理論探討
田笑新 , 丁寧 , 王永濤 , 徐世杰     
中國中醫科學院中醫基礎理論研究所,北京 100700
摘要:目前大多數中醫學者對心臟神經官能癥的發病與治療多從心、肝、脾、腎出發,較少論及肺。從心肝肺影響氣血運行的角度,以陰陽、五行、精氣血、津液神及經絡學說為工具,通過論述肝與肺的功能及生理病理特性,即“肺藏魄”“肺在聲為哭”“在志為悲”“肝主疏泄”“肝為五臟之賊”,生理上,心肝相生為母子,行血與藏血互用;心肺互制同居上焦,氣血互用;肝肺互制,龍虎回環調暢氣機。病理上,肝在五行屬木,木易郁而心火塞,從而乘肺金致肺氣虛。同時結合現代研究,提出心臟神經官能癥起于肝郁,而肝郁肺虛是心臟神經官能癥的病機演變結局之一的觀點,并提出論治心臟神經官能癥當需辨證論治,對于肝郁肺虛證的患者可疏其肝郁、補其肺氣。
關鍵詞心臟神經官能癥    肝郁    肺氣虛    

心臟神經官能癥是中樞神經系統功能失調引起的心血管功能紊亂綜合征。主要表現為心悸、氣短、胸悶、心前區疼痛甚則心絞痛、呼吸困難、失眠多夢、悲傷欲哭、煩躁焦慮等。由于這些主觀癥狀已經嚴重影響心臟神經官能癥患者的正常生活質量,但其相關檢查指標大多無明顯異常,西醫目前尚無較好的干預方案,而中醫藥干預對恢復患者正常生活質量有其獨特優勢。針對心臟神經官能癥的臨床特點,探討心臟神經官能癥的發病機制,為論治心臟神經官能癥提出了新的中醫藥方案,以期為中醫臨床提供新的指導意義。

1 心臟神經官能癥的發病機制 1.1 多起于肝氣郁

現代研究認為[1]心血管系統受神經及內分泌系統雙重調節,而神經內分泌系統對應于中醫理論則多由肝心參與并支配?!端脑\抉微·足厥陰肝經》云:“呵欠面青,驚悸,心肝并見?!毙母卧谖逍袑獮槟缸雨P系,心為肝之子,受肝影響與調配。中醫學認為,肝為“剛臟”,存剛強躁急之性,其氣升發,能啟迪諸臟,使諸臟之氣生升而沖和,《外經微言·寒熱舒肝篇》云:“肝喜疏泄,不喜閉藏?!爆F今人群壓力增大,從而情志不得舒展,閉藏于內,觸動于肝則表現為易亢易逆易郁的趨勢,肝母先病,心子必承之,進而出現如煩躁焦慮、失眠多夢、胸悶、氣短等心臟神經官能癥臨床證候群。

1.2 發于肺之神志聲異常

《靈樞·五癃津液別第三十六》云:“五臟六腑之津液,盡上滲于目,心悲氣并,則心系急。心系急則肺舉,肺舉則液上溢。夫心系與肺,不能常舉,乍上乍下,故咳而泣出矣?!贝伺c肺在志為悲相通。心臟神經官能癥患者神志異常的癥狀多表現為失眠、心煩、善悲等多與五神五志的失常有關,大多學者已論述其與心、肝有關,尚未涉及肺,但從理論探求,實則與肺亦有較大相關。宋建平團隊研究發現[2],肺對于多種激素如多巴胺、去甲腎上腺素、5-羥色胺等具有滅活作用,這是肺導致人體產生低落情緒的作用機制之一,與中醫學的“肺主悲”“其聲在哭”的觀點一致?!吨剌媷朗蠞健ふ缯撝巍氛J識到心疾日久而易悲憂,故曰:“怔忡不已,變生諸證,舌強恍惚,善憂悲?!睕r心臟神經官能癥起于肝郁,肝郁便侮肺金,肺又為嬌臟,見肝之壓制,則肺氣削弱而成虛,肺虛則更動悲傷情緒,易于哭泣,甚則反侮心火,致使心神不守而加重心系癥狀,如失眠、心煩、心悸等。

肺藏魄,魄不藏則感覺異常。魄主人體無意識的感覺狀態[3],西醫學表示當患者情緒、心理、精神等無意識活動受到刺激后,其中樞神經系統的抑制與興奮功能發生障礙,從而對植物神經的調節不合理,致使心血管系統出現紊亂、交感神經張力異常增大而出現的病癥[4]。

1.3 演變為木郁火塞而乘金

足厥陰肝經與手太陰肺經相連相通?!鹅`樞·經脈》謂足厥陰肝經“其支者,復從肝,別貫膈,上注肺”,故肺氣不達,則肝氣不利。而氣之為病多分為兩大類:氣虛與氣滯。金永梅等[5]認為肝郁為心臟神經官能癥的基本病機之一。其不足,則己所不勝侮而乘之,己所勝輕而侮之?!备斡魟t氣升失常,木郁不達,木氣壅盛侮于肺金,肺金反受制衡,更受心火之乘,氣滯與氣虛兼見,氣滯多在肝,氣虛多在肺,故可出現肝郁肺虛的病理機制,故心臟神經官能癥患者常表現為心悸、氣短、呼吸困難、胸悶、煩躁焦慮等??傊居艋鹑?,火塞一方面導致火無處宣泄而行克制金;另一面致使火不生土,而土為金之母,土不生則金累損。以上均為木火不良流通,從而直接影響到肺,故肝氣剛,肺氣損。

2 解肝郁以疏肝為要

五運六氣理論中[6]論述五郁之郁氣是指被勝氣所抑郁的氣。同時又指出“木郁達之”,其中“達”為“條達”“疏達”之意,即解肝郁應以疏解肝氣為要。疏肝多選用逍遙散、四逆散、柴胡疏肝散、舒肝丸等。研究表明[7-8]柴胡中藥制劑與逍遙散能改善心臟神經官能癥患者的臨床癥狀,比用西藥治療療效顯著提高,且不良反應較少。疏肝要中病即止[9],劑型以散劑為好,若作煎劑不可久煎,恐影響藥物效果,一般以煎15 min左右為宜,以空腹或半饑飽服為宜。疏解肝氣還應掌握在木氣發氣先兆到來之時予以治療干涉。

3 肺虛以治肺為主 3.1 肺氣虛當助肺氣而制心火

五行理論中火能克金,肺氣虛心火即來乘之。故肺氣虛在扶助肺氣的同時,當佐以承制心火。傅山治療怔忡、不寐、心悸時選用其驗方“安寐丹”,方取酸棗仁湯之意養肝血,合用生脈散補肺氣制心火[10];方藥中補肺多選用補肺阿膠湯、生脈散、麥冬湯之類,常用人參、黃芪、麥冬、五味子、阿膠、銀耳、冬蟲夏草之藥,認為此藥物可常服,但需在其中配伍適當健脾和胃之藥,以求剛柔相濟,消補并行,多選擇湯劑或膏劑,以間斷服用為宜,當癥狀基本控制后可改服丸劑;承制心火常用玄參、竹葉、麥冬、梔子、地黃等藥。

3.2 通因通用當利肺氣以補氣

心臟神經官能癥患者常見癥狀即為胸痹心痛,在《靈樞·厥病》中明確提出肺心痛這一名詞,謂“厥心痛,臥若徒居,心痛間,動作,痛益甚,色不變,肺心痛也,取之魚際、太淵?!濒~際為手太陰肺經之滎穴,滎主身熱;太淵為手太陰肺經之輸穴與原穴,輸主體重節痛,原穴為臟腑之氣流注匯聚之處,此選穴意為肺心痛者急需疏利肺之氣機,以安肺主治節之功。

3.3 肺虛神亂可補肺通神

百合與桂枝為補肺通神的要藥?!渡褶r本草經》云:“百合,味甘性平。主治邪氣腹脹。心痛……補中益氣?!庇纱艘姲俸蠁斡每芍餍耐?,觀張仲景所論百合病之神志異常與心臟神經官能癥頗為相似,其選方譬如百合地黃湯,以味甘之百合配伍味苦寒之生地黃,甘以補,苦以泄,寒以清,且《素問·臟氣法時論》曰:“肺色白,宜食苦?!贝烁士嗪嫌?,剛柔并濟。百合乃得土金之氣,入心肺二經,神志失常而見涕淚用百合效佳。又譬如百合知母湯、百合雞子湯、百合洗方及百合滑石散,此用藥皆以百合為君,蘊含肺之變而悲生淚流,且影響心肝的病機。

肺朝百脈,桂枝益肺,能益宗氣以行呼吸、主治節;桂枝暢達肝氣則肝能疏泄氣血;桂枝溫心則能行血脈,觀張仲景用桂枝加甘草治療奔豚之氣從少腹上沖心者,桂枝量倍于甘草以治其人叉手自冒心者;用茯苓甘草湯,茯苓桂枝等量以治心下悸者,均與心臟神經官能癥癥狀相似。桂枝更能通神,許源等[11]研究發現桂枝中桂皮醛具有鎮靜和抗驚厥作用,能改善心臟神經官能癥患者神經系統紊亂所造成的感覺障礙,如心痛、失眠、煩躁等。張仲景用柴胡桂枝湯、柴胡加龍骨牡蠣湯、桂枝去芍藥加蜀漆牡蠣龍骨救逆湯等均用桂枝以通神。

4 小結

中醫藥對于心臟神經官能癥的干預有獨特優勢,筆者從心肝肺之間的生理病理聯系出發,對心臟神經官能癥的發病、癥狀與治療進行了闡述,提出了木郁火塞而克金,從而形成肝木郁、肺金損的心臟神經官能癥發病特點,并結合文獻與臨床,認為解肝郁以溫肝疏肝為要,常用逍遙散、四逆散、柴胡疏肝散、舒肝丸等,要中病即止;補肺金需助肺氣而制心火,通因通用可選穴魚際與太淵,補肺通神可用藥百合與桂枝。

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Theoretical discussion on treating cardiac neurosis from liver depression and lung deficiency
TIAN Xiaoxin , DING Ning , WANG Yongtao , XU Shijie     
Institute of Basic Theory for Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China
Abstract: At present, most Chinese medicine practitioners treat cardiac neurosis (CN) from the heart, liver, spleen and kidney, rarely discuss the lung. And this article uses the hexagrams and the theory of the five elements as tools, from the perspective of the heart, liver and lung's movement of qi and blood and discusses the functions and physiological and pathological characteristics of the liver and lungs, namely, "lung holds the soul" "lung is crying" and "lung is determined to be sad" "liver governs dispersal" "liver is the thief of the five internal organs". Physiologically, the heart and the liver are born as mother and child, the blood circulation and storage are mutually used; the heart and lungs interact with each other in shangjiao and the qi and blood are mutually used. Liver and lungs interact with each other system, the dragon and tiger loop to adjust the air machine. Pathologically, the liver belongs to the wood in the five elements and the wood is easy to be stagnant and the heart is blocked by fire, which leads to lung qi deficiency by taking advantage of the lung gold. Furthermore, it is proposed that CN originates from stagnation of the liver and liver stagnation and lung deficiency is one of the outcome of the pathogenesis of CN. It is also proposed that the treatment of CN should be based on syndrome differentiation. For patients with liver stagnation and lung deficiency, lung qi can be supplemented and liver can be soothed and gloomy. At the same time, it discusses its specific treatment methods based on the theory of luck and depression, the experience of ancient physicians and modern classic cases, in order to provide a new perspective and reference for the clinical treatment of CN.
Key words: cardiac neurosis    liver depression    lung qi deficiency    
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