| 摘要: |
| [目的] 評價銀黛湯加減對于兒童重癥肺炎支原體肺炎（毒熱閉肺證）患兒氣道黏膜的改善情況。[方法] 收集重癥肺炎支原體肺炎毒熱閉肺證患兒90例，采用隨機數字表法隨機分為試驗組和對照組，其中3例患兒因病情加重、未規律服用中藥，予以剔除，最終納入87例患兒，其中試驗組44例，對照組43例。兩組均給予西醫常規治療，試驗組加用銀黛湯加減口服10 d。分別在治療前、治療后10 d，比較兩組癥狀評分，進行總療效評估。治療后3 d，觀察兩組患兒纖維支氣管鏡的鏡下表現，治療后10 d，45例患兒再次行纖維支氣管鏡治療，對比兩次纖維支氣管鏡下氣道黏膜的變化。[結果] 治療后10 d，試驗組癥狀總分低于對照組，差異具有統計學意義（P<0.05）。兩組纖維支氣管鏡鏡下表現比較中，治療后10 d，試驗組炎性狹窄、分泌物增多的發生率低于對照組，差異具有統計學意義（P<0.05）。[結論] 銀黛湯加減輔助西醫治療重癥肺炎支原體肺炎毒熱閉肺證患兒，可明顯改善支氣管氣道黏膜情況，有利于疾病恢復，提高臨床療效。 |
| 關鍵詞: 兒童重癥肺炎支原體肺炎 毒熱閉肺證 銀黛湯 纖維支氣管鏡檢查 |
| DOI：10.11656/j.issn.1672-1519.2023.05.05 |
| 分類號:R272 |
| 基金項目:北京市醫管中心培育計劃項目（PZ2021026）。 |
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| Observation on the improvement of Yindai Decoction on the airway mucosa of children with severe mycoplasma pneumoniae pneumonia from the microscopic level |
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HOU Yue, CHEN Fang, LIU Jing, LI Yanan
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Department of Traditional Chinese Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China
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| Abstract: |
| [Objective] To evaluate the effect of Yindai Decoction on the improvement of airway mucosa in children with severe mycoplasma pneumonia （toxin heat closing lung syndrome）. [Methods] Total 90 children with severe pneumonia caused by Mycoplasma pneumoniae diagnosed toxin heat closed lung syndrome be randomly divided into an experimental group and a control group. Among them, 3 children were excluded due to worsening of the condition and irregular use of traditional Chinese medicine. Finaｌｌｙ，87 children were included, and 44 in the experimental group and 43 in the control group.. Both groups were treated with routine Western medicine，and the test group was treated with Yindai Decoction for 10 days. The symptom scores of the two groups were compared before treatment and 10 days after treatment，and the total efficacy was evaluated. On the 3rd day after treatment，the bronchoscopic manifestations of the two groups of children were observed. On the 10th day after treatment，45 children were treated with bronchofibroscope again，and the changes of airway mucosa under bronchofibroscope were compared. [Results] The 10 days after treatment，the symptom score of the test group was lower than that of the control group，the difference was statistically significant. In the comparison of fibrobronchoscopic manifestations between the two groups，the incidence of inflammatory stenosis and increased secretion in the test group was lower than that in the control group 10 days after treatment，with a statistically significant difference. [Conclusion] Yindai Decoction can significantly improve the condition of bronchial and airway mucosa in children with severe mycoplasma pneumoniae pneumonia，which is helpful for disease recovery and clinical efficacy. |
| Key words: severe mycoplasma pneumoniae pneumonia in children toxic heat blocking lung syndrome Yindai Decoction fiberoptic bronchoscopy |
